Nitrofurantoin renal dosing

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Actual: Use of nitrofurantoin can be problematic for patients with renal dysfunction. Reduced renal function may lead to toxicity due to an increase in nitrofurantoin serum levels. Impaired renal function also decreases the efficacy of nitrofurantoin as an antibacterial medicine in the urinary tract.
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Elderly. No dose adjustment is required for the elderly with normal renal function or creatinine clearance Following administration of nitrofurantoin doses

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antibacterial efficacy in this infection depends on the renal secretion of nitrofurantoin into the urinary tract with renal impairment, renal

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Use of nitrofurantoin in renal impairment. Adequate glomerular filtration and renal tubular secretion is needed to achieve an effective therapeutic concentration in the urine 1. In patients with normal renal function, therapeutic doses of nitrofurantoin are rapidly excreted into the urine with no build-up in the plasma.

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antibacterial efficacy in this infection depends on the renal secretion of nitrofurantoin into the urinary tract with renal impairment, renal

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As nitrofurantoin is renally excreted, renal impairment will lead to elevated serum nitrofurantoin levels and increase its systemic toxicity (White et al

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Nitrofurantoin and renal impairment. Nitrofurantoin is an oral antibiotic for the treatment and prevention of urinary tract infections (1) antibacterial efficacy in this infection depends on the renal secretion of nitrofurantoin into the urinary tract; with renal impairment, renal secretion of nitrofurantoin is reduced

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