Ganciclovir vs acyclovir

In cells infected with HSV, the viral thymidine kinase phosphorylates ganciclovir to the monophosphate form, and cellular enzymes convert the monophosphate to ganciclovir triphosphate similar to the mechanism of action (MOA) of acyclovir in HSV (Figure 1) . Unlike acyclovir, ganciclovir is phosphorylated in CMV infected cells as well.

In addition, ganciclovir should not be used for acyclovir-resistant HSV infections, because of cross-resistance. Ganciclovir and acyclovir share the same

The most common adverse and toxic side effects, as determined from pooled data from all four major studies, were blurred vision (ganciclovir 57.8%, acyclovir 71.3%), eye irritation (ganciclovir 25.6%, acyclovir 46.2%), punctate keratitis (ganciclovir 8.8%, acyclovir 16%), and conjunctival hyperemia (ganciclovir 5.6%, acyclovir 5%).5 Bausch and

Acyclovir V/S Ganciclovir Ganciclovir differ from acyclovir by a single carboxyl side chain.

by SM Flechner 2024 Cited by 142Symptomatic CMV disease occurred in 9 of 14 (64%) of the acyclovir patients, two with tissue-invasive disease. Infection rates for acyclovir vs. ganciclovir

doses of acyclovir or ganciclovir per oral was still an option of therapy. However, oral ganciclovir is currently out of production and CMV management

The side effects of acyclovir include phlebitis, GI upset, and nephrotoxicity. Ganciclovir (Cytovene). Ganciclovir is used to treat

by M Martin 2024 Cited by 104alone or ganciclovir followed with acyclovir (65% vs. 50%). (Table 3). The greatest effect of early ganciclovir prophylaxis was on the

(acyclovir) vs placebo in 104 kidney transplant patients. Ganciclovir Valganciclovir vs Ganciclovir for the Prevention of CMV Disease in D/R